Progesterone increases Re: Risk of breast cancer with HRT depends on therapy type and duration
Agreement: I AgreeBody: Dear Editor
The rapid response from Dr Peter Lewis claims again that only synthetic progestogens increase the risk of breast cancer and not progesterone. In fact, the Collaborative Group on Hormonal Factors in Breast Cancer reviewed all the available relevant randomised evidence and found a significant nearly double increased risk of breast cancer with use of micronized progesterone (RR 1.93 (1.84-2.01).
Colonel Sir George Thomas Beatson was able to remit metastatic breast cancer as early as 1896 by removing functioning ovaries prevent endogenous secretion of oestrogens and progesterone. Oophorectomy became the standard treatment for advanced breast cancer and Beatson is considered the father of anti-hormonal treatment of breast cancer. His results make nonsense of HRT which probably became fashionable because use of progestogenic contraceptives block ovarian function and increase the chance of post-pill amenorrhoea or early menopause.
1 Collaborative Group on Hormonal Factors in Breast Cancer. Type and Timing of menopausal therapy and breast cancer risk individual participant meta-analysis of the worldwide epidemiological evidence. Lancet 2019;394 1159-68. :10.1016/S0140-6736(19)31474332.
No competing Interests: YesThe following competing Interests: Electronic Publication Date: Thursday, March 17, 2022 – 11:36Highwire Comment Subject: Risk of breast cancer with HRT depends on therapy type and durationWorkflow State: ReleasedFull Title: Progesterone increases Re: Risk of breast cancer with HRT depends on therapy type and duration
Highwire Comment Response to: Risk of breast cancer with HRT depends on therapy type and durationCheck this box if you would like your letter to appear anonymously:: Last Name: GrantFirst name and middle initial: Ellen CGEmail: firstname.lastname@example.orgAddress: Kingston-upon-Thames, SurreyOccupation: Physician and medical gynaecologistAffiliation: RetiredBMJ: Additional Article Info: Rapid response